X-linked Lymphoproliferative Disease (XLP)

X-linked lymphoproliferative disease (also called Duncan's Disease or Purtilo Syndrome) is an extremely rare disorder of the immune system which usually shows itself with infectious mononucleosis, dysgammaglobulinemia (abnormal levels of some types of antibodies), and lymphoma (a cancer of the lymphatic system). It may also cause lymphatic vasculitis, aplastic anemia and lymphomatoid granulomatosis.

One immune reaction caused by this syndrome causes the production of too many lymphocytes which then attack the bone marrow, and liver, and may damage the spleen, heart, kidneys and other organs.

It is estimated to affect one to three of every million males.