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Spina Bifida Research

Lurie Children’s Spina Bifida Center is a member of the National Spina Bifida Patient Registry, a network of clinics funded by the Center for Disease Control (CDC) to collect information regarding spina bifida. This information will be used in research efforts to establish guidelines and improve outcomes for those with spina bifida. We are one of twenty-four active sites who participate in the National Spina Bifida Registry as well as one of nine active sites who participate in the Urological Management of Newborns with Spina Bifida.

We are also involved in cutting edge research to examine shunt placement rates and the relationship between neuropsychological and psychosocial outcomes for children with myelomeningocele who have or do not have a shunt.

Ongoing Research Studies:

  • Long Term Follow Up of Patients with Spina Bifida: An Outcome Study
  • Neuropsychological and Psychosocial Outcomes for Children with Myelomeningocele in Relationship to their Shunt Status
  • Prospective measurement of renal function and variation in children and young adults with spina bifida
  • Scoliosis patterns in Children with Myelomeningocele: Does Curve pattern Predict Etiology?

Published Research

Bowman RM, McLone DG, Grant JA, Tomita T, Ito JA. Spina bifida outcome: a 25-year prospective. Pediatr Neurosurg. 2001 Mar;34(3):114-20.PMID: 11359098

Bowman RM, Mohan A, Ito J, Seibly JM, McLone DG. Tethered cord release: a long-term study in 114 patients. J Neurosurg Pediatr. 2009 Mar;3(3):181-7. doi: 10.3171/2008.12.PEDS0874.PMID: 19338463.

Swaroop VT, Dias L. Orthopedic management of spina bifida. Part I: hip, knee, and rotational deformities. J Child Orthop. 2009 Dec;3(6):441-9. doi: 10.1007/s11832-009-0214-5. Epub 2009 Oct 25. PMID: 19856195

Bowman, R. M. and McLone, D. G. Neurosurgical management of spina bifida: research issues. Dev Disabil Res Rev. 2010;16(1):82-7. doi: 10.1002/ddrr.100. PMID: 20419775

Swaroop VT, Dias L. Orthopaedic management of spina bifida-part II: foot and ankle deformities. J Child Orthop. 2011 Dec;5(6):403-14. doi: 10.1007/s11832-011-0368-9. Epub 2011 Sep 20.PMID: 23205142

Snow-Lisy DC, Yerkes EB, Cheng EY. Update on urological management of spina bifida from prenatal diagnosis to adulthood. J Urol. 2015 Aug;194(2):288-96. doi: 10.1016/j.juro.2015.03.107. Epub 2015 Apr Review. PMID: 25839383

Routh JC, Cheng EY, Austin JC, Baum MA, Gargollo PC, Grady RW, Herron AR, Kim SS, King SJ, Koh CJ, Paramsothy P, Raman L, Schechter MS, Smith KA, Tanaka ST, Thibadeau JK, Walker WO, Wallis MC, Wiener JS, Joseph DB. Design and Methodological Considerations of the Centers for Disease Control and Prevention Urologic and Renal Protocol for the Newborn and Young Child with Spina Bifida. J Urol. 2016 Dec;196(6):1728-1734. doi: 10.1016/j.juro.2016.07.081. Epub 2016 Jul 27. PMID: 27475969

Norkett W, McLone DG, Bowman RM. Current management strategies of hydrocephalus in the child with open spina bifida. Topics in Spina Cord Injury Rehabilitation. 2016; 22 (4):241-246.

Yerkes EB, Halline C, Yoshiba G, Meyer TA, Rosoklija I, Bowman R, McLone D, Cheng EY. Lipomyelomeningocele for the urologist: should we view it the same as myelomeningocele? J Pediatr Urol. 2017 May 22. pii: S1477-5131(17)30199-7. doi: 10.1016/j.jpurol.2017.04.014. [Epub ahead of print]
PMID: 28583853

Snow-Lisy DC, Halline C, Johnson EK, Diaz-Saldano D, Meyer T, Yerkes EB,
Reassessing the utility of routine urine culture with urodynamics: UTI incidence and risk factors, J Pediatr Urol. 2017 Aug;13(4):372.e1-372.e8. doi: 10.1016/j.jpurol.2017.05.013. Epub 2017 Jun 19. PMID: 28713003

Thompson RM, Foley J, Dias L, Swaroop VT. Hip status and long term functional outcomes in spina bifida. J Pediatr Orthop. 2018 Oct 8. doi: 10.1097/BPO.0000000000001266. [Epub ahead of print]. PMID: 30300276

Arkin C, Ihnow S. Dias L, Swaroop VT. Midterm results of the ponseti method for treatment of clubfoot in patients with spina bifida. J Pediatr Orthop. 2018 Nov/Dec; 38(10):e588-e592. doi: 10.1097/BPO.0000000000001248. PMID: 30199458