Program in Inflammation, Immunity, and the Microbiome



The Program in Inflammation, Immunity, and the Microbiome (PrIIMe) is dedicated to meeting the needs of pediatric patients with complex disorders of the immune system that affect multiple body systems. These types of immune dysregulation can include acute infections leading to sepsis, chronic conditions that alter the body’s immune system function such as immunodeficiencies or auto-immune disorders, or genetic conditions that affect the way body systems interact.

Immune dysregulation can be difficult to diagnose. It can affect many body systems at the same time, and symptoms may come and go. At Ann & Robert H. Lurie Children’s Hospital, we created a team of specialists from multiple areas that can be tailored to your child’s needs, including immunologists, oncologists, infectious disease specialists, critical care specialists, and rheumatologists. We partner with our immunology lab and genetic counselors to provide advanced diagnostics. Our goal is to gather input from all team members to provide an individualized diagnostic and treatment plan based on your child’s needs.


Conditions We Treat

We treat a variety of diseases with symptoms in multiple body systems as a result of disordered immunity including:

  • Critical complications of sepsis
  • Hemophagocytic lymphohistiocytosis (HLH)
  • Lymphoproliferative disorders
  • Undiagnosed diseases of immune dysregulation

Why Choose Lurie Children's?

PrIIMe includes specialists from across the hospital to meet your child’s specific needs. Lurie Children’s offers specialists in all aspects of the care that is required to diagnose and treat immune dysregulation. Patient support is critical to Lurie Children’s mission, and our dedicated team of social workers, case managers, and child life specialists are available during your stay and to help with transitions.

Our team collaborates with:

What To Expect

Whether your child is admitted to the hospital or visiting an outpatient clinic, upon referral to the PrIIMe team, our multi-disciplinary group of specialists will gather and review your child’s medical history. We may need to gather more information from laboratory testing, imaging, or other testing to help determine a diagnosis. We will work with your primary providers to create a diagnostic and treatment plan as applicable to your child’s needs. We will organize follow up with appropriate team members.

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