The Division of Rheumatology is engaged in research targeted to improve quality and outcomes for children who live with autoimmune and autoinflammatory disorders including childhood forms of arthritis, lupus and vasculitis. Each physician in our division takes on this charge through a different focus resulting in a multidisciplinary approach to reach our goals. These endeavors have fostered new approaches to diagnosis, treatment and translational research for many of these conditions, including:
Juvenile Dermatomyositis (JDM)
Childhood Onset Arthritis
Systemic Lupus Erythematosus (SLE)
Juvenile Idiopathic Arthritis (JIA)
Division physicians participate in national multicenter research coordinated through the Pediatric Rheumatology Collaborative Study Group (PRCSG), which focuses on drug trials, and the Childhood Arthritis and Rheumatology Research Alliance (CARRA), which focuses on disease management. They are also active in the International Myositis Assessment and Clinical Studies Group (IMACS).
Other research interests in the division include:
Measures of disease activity and remission
Biomarkers of disease activity
Patient registries documenting natural history of pediatric rheumatic diseases and treatment outcomes
Dr. Klein-Gitelman’s Research
Dr. Marisa Klein-Gitelman's research includes projects investigating disease outcomes and the burden of childhood rheumatic diseases. Dr. Klein-Gitelman is the site investigator for CARRA and PRCSG multicenter projects. She is also involved in projects investigating pediatric lupus including:
Evaluation of thinking processes at onset of lupus and potential damage over time.
Evaluation of genetic risk factors for lupus.
Assessment of tools to monitor pediatric lupus disease activity and damage.
Assessment of potential markers that detect the onset of disease activity.
Dr. Pachman’s Research
Dr. Lauren Pachman's research interests center on the regulation of the immune response, both in children with vascular involvement and rheumatic disease. Her specific focus is the study of factors affecting the onset and course of the most common pediatric inflammatory myopathy, juvenile dermatomyositis. The Pachman Laboratory uses translational and collaborative team approaches to study juvenile dermatomyositis (JDM), an often chronic pediatric systemic vasculopathy of unknown etiology. JDM is associated with inflammation in the skin, as well as in the proximal musculature – resulting in extensive weakness. The goal of their studies is to discover biomarkers of disease activity to guide the utilization and/or creation of more effective therapies.
Dr. Miller’s Research
Dr. Michael Miller’s research interests include health related quality of life in children with arthritis and related conditions. Dr. Miller studies the relationship of quality of life to disease subtype, severity, and related characteristics. This research will help improve outcomes by identifying those children as early as possible who will benefit from individualized coordinated medical and non-medical treatment. In his administrative role as Director, Research Informatics, Dr. Miller assists other researchers at Lurie Children’s Hospital in obtaining data from the electronic medical record and other data sources.
Dr. Ardalan’s Research
Dr. Kaveh Ardalan’s research interests and expertise are in patient-reported outcomes, outcomes research, psychometrics, qualitative research (specifically with children and families). He has a secondary appointment in the Department of Medical Social Sciences and is working on multidisciplinary research projects there to examine physical activity in juvenile myositis.
Dr. De Ranieri’s Research
Dr. Deirdre De Ranieri’s research focuses on the use of Musculoskeletal Ultrasound (MSUS) in Juvenile Idiopathic Arthritis (JIA). She is involved in the standardization of image acquisition and disease scoring in children with JIA and also uses MSUS to study subclinical synovitis in children with arthritis. She participates in studies of new drugs for treating children with JIA, and she is interested in synovial cell populations and their potential role in both predicting prognosis and directing more targeted therapies in children with JIA.
Continuation of the CARRA Registry as described in the protocol will support data collection on patients with pediatric-onset rheumatic diseases. The CARRA Registry will form the basis for future CARR...
The purpose of this multi-site randomized clinical trial is to determine if an online coping skills training program will produce superior improvements in pain and health-related quality of life outco...
The purpose of this study is to examine the long-term safety of Abatacept for the treatment of juvenile idiopathic arthritis (JIA) with particular in interest in the occurrence of serious infections, ...