The Anatomic Pathology Division offers state-of-the-art diagnostic services in Surgical Pathology, Cytopathology, Hematopathology and Autopsy Pathology. These four main areas are supported by a variety of laboratories including Histology, Hematology, Flow Cytometry, Microbiology, Molecular Genetics and Cytogenetics. Pathological material from outside institutions is reviewed upon request, with approximately 450 consultation cases per year.
Surgical Pathology is a comprehensive diagnostic service that processes over 6500 specimens every year. Our board-certified pathologists are experts in most subspecialty areas and offer complete services in pediatric surgical pathology. Areas of intense subspecialty expertise include the fields of neuropathology, gastroenterology and hepatic pathology, cardiac pathology, renal and genitourinary tumors (including Wilms tumor), germ cell tumors, hematopathology, lung pathology, soft tissue tumors, among others. Special procedures employed include immunohistochemistry, immunofluorescence, in situ hybridization, and molecular diagnosis by RT-PCR, FISH and Next-Generation Sequencing using the Pediatric Oncomine platform.
The Cytopathology service processes an average of 650 cytology preparations every year, corresponding mostly to bronchial alveolar lavages and body fluid cytology (CSF, pleural, peritoneal, pericardial fluids). Approximately 225 fine needle aspirations are performed annually which include thyroid, bone and soft tissue lesions, abdominal/thoracic tumors, among others.
The hematopathology service interprets approximately 350 bone marrows, and 100 lymph node and lymphoid tissue biopsies each year. We use a multidisciplinary approach that integrates the morphology, immunohistochemistry, flow cytometry immunophenotyping, traditional cytogenetics, and FISH, as well as molecular diagnostics. The common disease entities for which we have expertise include acute lymphoblastic Leukemia/lymphomas, acute myeloid leukemia/myeloid sarcomas, chronic myeloid leukemia, Burkitt lymphoma, Hodgkin lymphomas, NK and T cell neoplasms, histiocytic and dendritic cell neoplasms, congenital bone marrow failure syndromes, post-transplant lymphoproliferative disorders, and other neoplastic and non-neoplastic hematopoietic lesions.
The division of Anatomic Pathology performs post-mortem examinations by request of Lurie Children’s physicians on an average of 40 cases each year. In addition, the division is also very active in “Gift From A Child Program” supporting the research mission of the institution.
The Division of Anatomic Pathology supports also the academic missions of the hospital, as our pathologists are actively involved in clinical research projects and in the education of fellows, residents, medical students, and medical technology students.