Pediatric Ophthalmology Research

The Division of Ophthalmology is committed to advancing care through research. Our specialists are involved in a variety of projects that encompass multiple aspects of pediatric ophthalmology, including amblyopia, strabismus, cataracts, genetic eye disorders, ocular tumors, retinopathy of prematurity, visual examination, ocular imaging and education. This is being accomplished not only through our own institution’s research department, but also through collaborations with other academic centers and integrated national networks. Our division takes great care in compliance with federal, state and institutional regulations with regards to research to provide the best safety and care towards our patients.

Current Trials & Studies

Pediatric Eye Disease Investigator Group (PEDIG)

Funder/Sponsor: NEI/JAEB Center for Health Research

Enrolling

  • ATS22: A Randomized Trial to Evaluate Sequential vs Simultaneous Spectacles plus Patching for Amblyopia in Children 3 to <13 Years Old (PI:Kurup, S)

In follow-up

  • C02: Pediatric cataract surgery outcomes registry (PI: Rahmani, B)
  • IXT5: A randomized clinical trial to determine the long-term on-treatment and off-treatment effects on the control of intermittent exotropia (PI: Kurup, S)
  • IXT1: A randomized trial of bilateral lateral rectus recession versus unilateral lateral rectus recession with medial rectus resection for intermittent exotropia (PI: Rahmani, B)

Genetics

  • National Ophthalmic Genotyping Network, Stage 1: Creation of repository for inherited ophthalmic diseases (PI: Mets, M)
  • Ocular manifestations of connective tissue diseases (The Marfan Eye Consortium of Chicago): To evaluate baseline parameters in patients who are diagnosed with connective tissue diseases such as Marfan syndrome (PI: Mets, M)
  • Genetics of eye diseases (PI: Bohnsack, B)

Strabismus

  • Characterizing the individualized risk factors for unsuccessful outcome among pediatric patients receiving strabismus surgery for esotropia (PI: Rahmani, B)
  • Fusional Amplitudes in Strabismus Surgery (PI: Mets-Halgrimson, R)\
  • Baseline Characteristics and Outcomes in Intermittent Exotropia (PI: Kurup, S)

Glaucoma

  • Outcome of angle surgery for primary congenital glaucoma (PI: Rahmani, B)
  • Outcomes of patients with pediatric post-lensectomy glaucoma (PI: Rahmani, B)
  • Imaging and Diagnostic Modalities in Pediatric Glaucomas (PI: Bohnsack, B)

Ophthalmologic Examination & Imaging

  • Quantitative pupillometry in pediatric patients evaluate for papilledema (PI: Kurup, S)
  • Normal Values for Standard Full Field Electroretinography in a Tertiary Care Pediatric Population in Chicago (PI: Mets. M)

Oncology

  • Long-term follow-up of patients with NF-1 associated optic pathway glioma (PI: Zeid, J)
  • Cost analysis of different treatments for retinoblastoma (PI: Rahmani, B)
  • Global presentation of retinoblastoma (PI: Mets, M)
  • Developing Evidence-Based Criteria for Initiating Treatment for Neurofibromatosis Type 1 Associated Optic Pathway Glioma (PI: Goldman, S, Sub-I: Zeid, J)
  • Retinoblastoma Patient Clinical Database and Tissue Repository (PI Zeid, J, in collaboration with Dr Berry at Children’s Hospital Los Angeles)
  • Visual outcomes of after eye-saving retinoblastoma treatments (PI: Mets-Halgrimson, R)

Retinopathy of Prematurity

  • Review of retinopathy of prematurity patients at Children’s Memorial Hospital and Prentice Women’s Hospital (PI: Yoon, H)
  • Tear biomarkers as prognostic indicators of infants who are at risk of developing severe of retinopathy of prematurity: a pilot data (PI: Yoon, H)
  • Foveal microvascular analysis on OCTA and the correlation with foveal thickness and visual acuity in ROP treated with anti-vascular endothelial factor (anti-VEGF) (PI: Rahmani, S)
  • Neurodevelopmental outcomes of infants treated with bevacizumab for retinopathy of prematurity (PI: Rahmani, S)

Ocular and Visual Development

  • Normal growth patterns of axial length, keratometry, and cycloplegic refraction in the first ten years of life
  • Concussion, Visual Processing and Treatment (PI: Stec, M)
  • Visual function in patients with a history of hypoxic ischemic encephalopathy (PI: Shaikh, N)
  • Visual development of premature infants with intraventricular hemorrhage in a tertiary care hospital (PI: Yoon)
  • Eye manifestations in children with Turner syndrome (PI: Mets-Halgrimson, R)

Medical and Surgical Management

  • Pediatric Cataract Surgery Outcomes at Lurie Children's (PI: Rahmani, B)
  • Investigation of ocular outcomes before and after craniofacial surgery of children with craniosynostosis (PI: Rahmani, B)
  • Outcome of Orbital Cellulitis in Pediatric Patients at Lurie Children's (PI: Rahmani, B)
  • Alternative Surgical Technique for the Removal of Pediatric Orbital Dermoid Cysts (PI: Rahmani, B)
  • Tarsorraphy: Clinical Experience at Lurie Children's (PI: Rahmani, B)
  • Horizontal deviations in double elevator palsy – characteristics and surgical outcomes (PI: Rahmani, B)
  • Retrospective Study of Periocular and Orbital Lymphaticovenous Malformations (PI: Rahmani, B)
  • Pain after strabismus surgery: post-operative outcomes using courses of acetaminophen in children (PI: Yoon, H)
  • Management of acute-onset, comitant esotropia: An international experience (PI: Laurenti, K in collaboration with Boston Children’s Hospital)

Clinical Trials

  • ClinicalTrial.gov ID: NCT04378790
    ATS22: A Randomized Trial to Evaluate Sequential vs Simultaneous Spectacles plus Patching for Amblyopia in Children 3 to <13 Years Old (PI: Kurup, S)
  • ClinicalTrial.gov ID: NCT02807350
    Trial of Overminus Spectacle Therapy for Intermittent Exotropia (IXT5) (PI: Kurup, S)
  • ClinicalTrial.gov ID: NCT04101721
    Study to Assess the Efficacy, Safety, and Tolerability of Intravitreal Aflibercept Compared to Laser Photocoagulation in Patients With Retinopathy of Prematurity (BUTTERFLEYE) (PI: Rahmani, S)
  • ClinicalTrial.gov ID: NCT01032603
    Bilateral Lateral Rectus Recession Versus Unilateral Recess-Resect for Intermittent Exotropia (IXT1) (PI: Rahmani, B)
  • ClinicalTrial.gov ID: NCT02638220
    Cerebrotendinous Xanthomatosis (CTX) Prevalence Study