Pediatric Ophthalmology Research

The Division of Ophthalmology is committed to advancing care through research. Our specialists are involved in a variety of projects that encompass multiple aspects of pediatric ophthalmology, including amblyopia, strabismus, cataracts, genetic eye disorders, ocular tumors, retinopathy of prematurity, visual examination, ocular imaging and education. This is being accomplished not only through our own institution’s research department, but also through collaborations with other academic centers and integrated national networks. Our division takes great care in compliance with federal, state and institutional regulations with regards to research to provide the best safety and care towards our patients.

Current Trials & Studies

Pediatric Eye Disease Investigator Group (PEDIG)

Funder/Sponsor: NEI/JAEB Center for Health Research
  • C02: Pediatric cataract surgery outcomes registry
  • ATS20: A randomized clinical trial to evaluate the effectiveness of binocular game play in amblyopia treatment
  • IXT5: A randomized clinical trial to determine the long-term on-treatment and off-treatment effects on the control of intermittent exotropia
  • PON1:  Pediatric optic neuritis outcomes registry
  • SAS1: Registry of adult strabismus (e.g., convergence insufficiency, divergence insufficiency, or small-angle hypertropia) to evaluate characteristics, treatments and outcomes​
  • CITS: A randomized clinical trial of effectiveness of home-based therapy for symptomatic convergence insufficiency
  • HTS1: A randomized clinical trial of glasses versus observation for moderate hyperopia in young children
  • IXT1: A randomized trial of bilateral lateral rectus recession versus unilateral lateral rectus recession with medial rectus resection for intermittent exotropia
  • IXT2: A randomized clinical trial of observation versus occlusion therapy for intermittent exotropia
  • IXT3: A pilot randomized clinical trial of overminus spectacle therapy for intermittent exotropia
  • ATS18: Randomized trial to evaluate binocular computer activities for amblyopia


  • National Ophthalmic Genotyping Network, Stage 1: Creation of repository for inherited ophthalmic diseases
  • The Hutterites Eye Research Study: To gain a better understanding of genetic eye disease by analyzing data obtained from eye examinations in the Hutterite population of South Dakota
  • Ocular manifestations of connective tissue diseases (The Marfan Eye Consortium of Chicago): To evaluate baseline parameters in patients who are diagnosed with connective tissue diseases such as Marfan syndrome


  • Binocularity following surgical correction of the non-accommodative component in esotropia
  • The effect of surgical correction on stereoacuity in adult strabismus patients
  • The incidence of true strabismus following diagnosis of pseudostrabismus

Ophthalmologic Examination & Imaging

  • Macular and retinal nerve fiber layer thickness in children with unilateral amblyopia measured by spectral-domain ocular coherence tomography (SDOCT)
  • Homonymous visual field defect treatment and neuroretinal plasticity
  • Pediatric screening for vigabatrin ophthalmic toxicity
  • Quantitative pupillometry in pediatric patients evaluate for papilledema
  • Videotaping extraocular muscle examination by head-mounted camera in orthoptic and ophthalmology clinics
  • A comparison of Lang and Titmus Fly stereo tests

Education and Training

  • Pediatric Ophthalmology Inpatient Consults at a Tertiary Care Teaching Hospital: To identify the characteristics of inpatient consultations at Lurie Children’s and recommend guidelines for developing an ophthalmology consult service and resident consult curriculum at pediatric hospitals


  • Long-term follow-up of patients with NF-1 associated optic pathway glioma

Retinopathy of Prematurity

  • Review of retinopathy of prematurity patients at Children’s Memorial Hospital and Prentice Women’s Hospital

Ocular and Visual Development

  • Normal growth patterns of axial length, keratometry, and cycloplegic refraction in the first ten years of life

Medical and Surgical Management

  • Propranolol versus prednisone in treatment of periocular infantile hemangioma
  • Omeros Investigational New Drug: A randomized, double-masked, parallel-group, phenylephrine-controlled study of the effect of OMS302 added to the standard irrigation solution of intraoperative pupil diameter and acute postoperative pain in children ages birth to three years undergoing unilateral cataract extraction with our without lens replacement
    Funder/Sponsor: Omeros
  • A0661206: Ocular effects of azithromycin oral solution in pediatric patients with pharyngitis/tonsillitis 
    Funder/Sponsor: Pfizer