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Pediatric Ophthalmology Research

The Division of Ophthalmology is committed to advancing care through research. Our specialists are involved in a variety of projects that encompass multiple aspects of pediatric ophthalmology, including amblyopia, strabismus, cataracts, genetic eye disorders, ocular tumors, retinopathy of prematurity, visual examination, ocular imaging and education. This is being accomplished not only through our own institution’s research department, but also through collaborations with other academic centers and integrated national networks. Our division takes great care in compliance with federal, state and institutional regulations with regards to research to provide the best safety and care towards our patients.

Current Trials & Studies

Pediatric Eye Disease Investigator Group (PEDIG)

Funder/Sponsor: NEI/JAEB Center for Health Research

Enrolling

  • ATS22: A randomized trial to evaluate sequential vs. simultaneous spectacles plus patching for amblyopia in children 3 to <13 years old - S. Kurup

In follow-up

  • CO2: Pediatric cataract surgery outcomes registry - B. Rahmani
  • IXT5: A randomized clinical trial to determine the long-term on-treatment and off-treatment effects on the control of intermittent exotropia - S. Kurup
  • IXT1: A randomized trial of bilateral lateral rectus recession versus unilateral lateral rectus recession with medial rectus resection for intermittent exotropia - B. Rahmani

Genetics

  • Genetics of eye diseases - B. Bohnsack
  • Ocular genetics database for childhood retinal diseases, congenital cataracts, and pediatric glaucomas - J. Rossen

Strabismus

  • Management of acute-onset commitant esotropia - K. Laurenti in collaboration with Boston Children’s Hospital
  • Outcomes in intermittent exotropia - S. Kurup
  • Characterizing the individualized risk factors for unsuccessful outcome among pediatric patients receiving strabismus surgery for esotropia - B. Rahmani
  • Pain after strabismus surgery: post-operative outcomes using courses of acetaminophen in children

Visual Development and Amblyopia

  • Amblyopia treatment with binocular video games versus patching - B. Rahmani
  • Differences in myopia control - N. Shaikh and M. Stec

Glaucoma

  • Imaging and diagnostic modalities in pediatric glaucomas - B. Bohnsack
  • Outcomes of Pediatric glaucomas - B. Bohnsack

Neuro-Ophthalmology

  • Quantitative pupillometry in pediatric patients evaluated for papilledema - S. Kurup
  • Visual development of premature infants with intraventricular hemorrhage - H. Yoon
  • Concussion, visual processing and treatment - M. Stec
  • Visual function in patients with history of hypoxic ischemic encephalopathy - N. Shaikh
  • Eye manifestations in children with Turner syndrome - B. Bohnsack

Oncology

  • Long-term follow-up of patients with NF-1 associated optic pathway glioma - J. Zeid
  • Cost analysis of different treatments for retinoblastoma - B. Rahmani
  • Retinoblastoma patient clinical database and tissue repository - J. Zeid in collaboration with Children’s Hospital of Los Angeles
  • Visual outcomes of after eye-saving retinoblastoma treatments - J. Zeid
  • Developing evidence-based criteria for initiating treatment for Neurofibromatosis Type 1 associated optic pathway glioma - J Zeid in collaboration with S. Goldman

Retinopathy of Prematurity

  • A randomized trial of low-dose Bevacizumab versus laser for type 1 retinopathy of prematurity (ROP3) - H. Yoon
  • Bevacizumab treatment for posterior zone I retinopathy of prematurity (ROP4) - H. Yoon
  • Tear biomarkers as prognostic indicators of infants who are at risk of developing severe of retinopathy of prematurity - H. Yoon
  • Neurodevelopmental outcomes of infants treated with Bevacizumab for retinopathy of prematurity - H. Yoon
  • Foveal microvascular analysis on OCT-A and the correlation with foveal thickness and visual acuity in ROP treated with anti-vascular endothelial factor (anti-VEGF) - S. Rahmani

Anterior Segment and Cataract

  • Tear Biomarkers in Pediatric Inflammatory Ocular Surface Diseases - K. Laurenti
  • Comparison of Aphakic Contact Lenses in Children - N. Shaikh and M. Stec
  • Prevalence of Dry Eye Disease in Children - N. Shaikh

Eye Plastics and Orbital Diseases

  • Periocular and orbital lymphaticovenous malformations - B. Rahmani
  • Pediatric lid lacerations - J Rossen
  • Pediatric idiopathic orbital inflammation - B. Rahmani

Pediatric Ophthalmology Training

  • Improving pediatric ophthalmology fellowship recruitment and training - J. Rossen and H. Yoon

Clinical Trials

  • ClinicalTrial.gov ID: NCT04378790
    ATS22: A Randomized Trial to Evaluate Sequential vs Simultaneous Spectacles plus Patching for Amblyopia in Children 3 to <13 Years Old (PI: Kurup, S)
  • ClinicalTrial.gov ID: NCT02807350
    Trial of Overminus Spectacle Therapy for Intermittent Exotropia (IXT5) (PI: Kurup, S)
  • ClinicalTrial.gov ID: NCT04101721
    Study to Assess the Efficacy, Safety, and Tolerability of Intravitreal Aflibercept Compared to Laser Photocoagulation in Patients With Retinopathy of Prematurity (BUTTERFLEYE) (PI: Rahmani, S)
  • ClinicalTrial.gov ID: NCT01032603
    Bilateral Lateral Rectus Recession Versus Unilateral Recess-Resect for Intermittent Exotropia (IXT1) (PI: Rahmani, B)
  • ClinicalTrial.gov ID: NCT02638220
    Cerebrotendinous Xanthomatosis (CTX) Prevalence Study