Pediatric Neurosurgery Research

Our multidisciplinary team is committed to research that will translate to a better understanding of pediatric brain tumors. Division Head Tadanori Tomita, MD, serves on numerous national and international committees. He is a full member of the internationally recognized Children's Oncology Group's Brain Tumor Core Committee and has served as the neurosurgical coordinator in various protocols. Throughout his career, Dr. Tomita has contributed to the advancement of pediatric neuro-oncology in more than 100 peer-reviewed papers.

Published Research

Examples of the division's published research include:

  • Pulcrano M, Chahine AA, Saratsis AM, Divine-Cadavid J, Narra V, Evans SR. Putting Residents in the Office: An Effective Method to Teach the Systems-Based Practice Competency. J Surg Educ. 2014 Oct 10. PMID: 25312297.
  • Kambhampati K , Perez J , Yadavilli S, Saratsis AM, Hill DA , Ho C , Panditharatna E , Markel M , Packer RJ, Nazarian J.  A Standardized Autopsy Procurement Allows for the Comprehensive Study of DIPG Biology. Oncotarget. E-publication 2015 Jan 24. PMID: 25749048
  • Yadavilli S, Scafidi J , Becher O , Saratsis AM, Hiner R , Kambhampati M, Mariarita S, MacDonald T , Codispoti K , Jaiswal J , Packer RJ, Nazarian J. The Emerging Role of NG2 in Pediatric Diffuse Intrinsic Pontine Glioma. Oncotarget. E-publication 2015 March 30.  PMID: 25987129
  • CD133 and DNA-PK regulate MDR1 via the PI3K- or Akt-NF-κB pathway in multidrug-resistant glioblastoma cells in vitro. Xi G, Hayes E, Lewis R, Ichi S, Mania-Farnell B, Shim K, Takao T, Allender E, Mayanil CS, Tomita T. Oncogene. 2015 Mar 30.
  • Sredni St and Tomita T. Rhabdoid Tumor Predisposition Syndrome. Ped. Dev Pathol. 18(1):49-58, 2015. PMID: 25494491.
  • Malchendo S, Sredni St, Hashimoto H, Kazai A, Nagayasu K, XIE J, Margaryan N, Seiriki K, HENDRIX MJC, SOARES MB. A Mouse model of radial glial cell – derived primitive neuroectodermal tumors. PLoS One. 2015 Mar 31;10(3): e0121707. PMID: 25826270
  • Angiopoietin-1 Regulates Brain Endothelial Permeability through PTPN-2 Mediated Tyrosine Dephosphorylation of Occludin. Siddiqui MR, Mayanil CS, Kim KS, Tomita T. PLoS One. 2015 Jun 19;10(6):e0130857. doi: 10.1371/journal.pone.0130857. eCollection 2015. PMID:26090670
  • Rhabdoid tumor predisposition syndrome. Sredni ST, Tomita T. Pediatr Dev Pathol. 2015 Jan-Feb;18(1):49-58. doi: 10.2350/14-07-1531-MISC.1. Epub 2014 Dec 10.
  • Postshunt lateral ventricular volume, white matter integrity, and intellectual outcomes in spina bifida and hydrocephalus. Williams VJ, Juranek J, Stuebing KK, Cirino PT, Dennis M, Bowman RM, Blaser S, Kramer LA, Fletcher JM. J Neurosurg Pediatr. 2015 Apr;15(4):410-9. doi: 10.3171/2014.10.PEDS13644. Epub 2015 Jan 30.
  • Squamosal suture craniosynostosis due to hyperthyroidism caused by an activating TSH receptor mutation (T632I). Chawla R, Alden TD, Bizhanova A, Kadakia R, Brickman W, Kopp PA. Thyroid. 2015 Jun 26. [Epub ahead of print] PMID:26114856
  • Diagnostic evaluation, monitoring, and perioperative management of spinal cord compression in patients with Morquio syndrome. Charrow J, Alden TD, Breathnach CA, Frawley GP, Hendriksz CJ, Link B, Mackenzie WG, Manara R, Offiah AC, Solano ML, Theroux M. Mol Genet Metab. 2015 Jan;114(1):11-8. doi: 10.1016/j.ymgme.2014.10.010. Epub 2014 Oct 30. PMID: 25496828
  • Endoscopic endonasal surgery for sinonasal and skull base lesions in the pediatric population. Rastatter JC, Snyderman CH, Gardner PA, Alden TD, Tyler-Kabara E. Otolaryngol Clin North Am. 2015 Feb;48(1):79-99. doi: 10.1016/j.otc.2014.09.007. PMID 25439550
  • Tomita, T., Gorahovac, G.: Cerebellopontine Angle Tumors in Infants and Children. Childs Nerv Syst. 2015 Oct;31(10):1739-    50. doi:     10.1007/s00381-015-2747-x. Epub 2015 Sep 9. PMID: 26351227
  • Dipatri, A.J., Sredni, S.T., Grahovac, G., Tomita, T.: Atypical Teratoid Rhabdoid Tumors of the Posterior Fossa in Children. Childs Nerv Syst. 2015 Oct;31(10):1717-28. doi: 10.1007/s00381-015-2844-x. Epub 2015 Sep 9. PMID: 26351225