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Pediatric Epilepsy Research

Here at Lurie Children’s, our research team works tirelessly to bring our patients and families an abundance of clinical research opportunities, in a mission to discover new cures, every day. Our multidisciplinary team of physician-scientists conduct various research projects to help promote patient care and better educate families. We participate in studies funded by the National Institute of Health (NIH), pharmaceutical companies and our own investigator-initiated studies. We hope our research efforts will improve treatment for children with epilepsy.

Our current focus is in precision medicine, which strives to determine optimal personalized treatment methods based on genetic testing results. We hope to achieve the same success as with our existing studies, which will help our patients tremendously.

Learn more about Epilepsy Precision Medicine - Research Studies

Current Epilepsy Center Clinical Trials

An Open-Label Study to Investigate the Safety and Pharmacokinetics of Single and Multiple Ascending Doses of Antisense Oligonucleotide STK-001 in Children and Adolescents with Dravet Syndrome

An Open-Label Extension Study for Patients with Dravet Syndrome who Previously Participated in Studies of STK-001

Natural History Study of Infants and Children with SCN1A-positive (SCN1A+) Dravet (ENVISION)

A Phase 3 Study of Adjunctive XEN496 in Pediatric Subjects with KCNQ2 Developmental and Epileptic Encephalopathy

An Open-label, Randomized Trial to Assess the Safety, Pharmacokinetics, and Exploratory Efficacy of Adjunctive Cannabidiol Oral Solution (GWP42003-P) Compared with Standard of Care Antiepileptic Therapy, in Patients Age 1 Month to Less Than 12 Months of Age with Tuberous Sclerosis Complex Who Experience Inadequately-controlled Seizures

Copper Histidinate Treatment for Menkes Disease

Ketogenic Diet with D,L-Beta-Hydroxybutyrate Medical Food Formulation for Pediatric Patients with Drug Resistant Epilepsy (KEEPER)

  • IRB #: 2020-3267
  • Study Contact: Enrique Rojas, erojas@luriechildrens.org & Marija Stosic, mstosic@luriechildrens.org
  • PI: Dr. Joyce Wu
  • Description: This is an interventional study to assess the safety and tolerability of the ketogenic diet in combination with a ketogenic medical food formulation (medium chain triglycerides and beta-hydroxybutyrate, MCT and BHB) for use in children with drug resistant seizures.