Nager syndrome, also known as acrofacial dysostosis, is a rare genetic condition that causes physical abnormalities in several parts of the body, but most commonly the face, hands, and arms. Small or missing thumbs are a usual feature of this syndrome. There may also be hearing loss, cleft palate, jaw deformities, and malformed ears.

Intellectual ability is not impaired, though communication ability may be delayed due to hearing loss. At birth, breathing and eating may have to be assisted due to abnormalities in the airway. Corrective and reconstructive surgeries will most likely begin shortly after birth.