Myelodysplastic syndrome (MDS) is a bone-marrow disorder primarily occurring in the elderly but also seen in younger patients. It is characterized by a failure of the bone marrow to produce mature healthy blood cells.
Though there are few symptoms at first, it causes fatigue, shortness of breath, bleeding issues, or frequent infections. Some forms of this syndrome develop into acute myeloid leukemia.
Allogeneic hematopoietic stem cell transplantation from a suitable donor is the treatment of choice for most children with MDS.