Metabolic Bone Disease

Metabolic bone disease is a group of disorders that affect bone metabolism, usually caused by abnormalities in minerals such as calcium or phosphorus and vitamin D. These disorders can be either genetic or acquired and may lead to reduced growth, deformities, and fractures causing bone pain, decreased mobility and other disabilities.

Examples of such diseases are osteoporosis, rickets, osteomalacia, renal osteodystrophy, sclerosing bony disorders, hypophosphatasia, fibrous dysplasia, skeletal dysplasia, juvenile Paget disease, familial expansile osteolysis, and osteoporosis pseudoglioma syndrome.

Detecting bone disease and treating it early is critical to minimizing disability in adulthood.