At Lurie Children’s we offer extracorporeal photopheresis (ECP) to treat graft-versus-host disease (GVHD) in children, a complication after a bone marrow transplant that may be life-threatening. The biggest potential benefit of ECP is that children can avoid taking drugs, like steroids, which suppress the immune system to treat GVHD. These drugs can be tapered off over time and stopped once the disease is brought under control by ECP. The problem with steroids and similar drugs is that they place patients at high risk of infection and can eventually harm various organs. ECP can be a safe and effective alternative. Children with GVHD that has not responded adequately to immune suppression with steroids and other medications may be considered for this therapy.