Barry K. Wershil, MD, and his lab staff are involved in a variety of research projects related to eosinophilic esophagitis. Dr. Wershil’s research interests include the role of mast cells in gastrointestinal inflammation and homeostasis. This work involves the use of mouse models to investigate mast cells and mast cell mediators in a variety of inflammatory reactions, including allergic, neurogenic and immune inflammation.
The lab is also interested in studying the pathogenesis of eosinophilic esophagitis, and specifically the mediators that influence the pathology of the esophagus by using immunohistochemistry and the molecular biology method.
"Understanding the Mechanism of Remodeling in EoE" involves studying the natural history and inflammation in the esophagus of patients with EoE.
Joshua Wechsler, MD, and his laboratory study the natural history and pathogenesis of eosinophilic esophagitis (EoE), with a goal of improving diagnostics and treatment outcomes. Dr. Wechsler collaborates with immunologists, cell biologists, and biostatisticians at Northwestern University Feinberg School of Medicine, on a variety of research projects. His laboratory is investigating the role of mast cells and their effector molecules in the mucosal inflammatory changes associated with EoE, as well as biomarkers and mediators of diet elimination. This involves both translational studies utilizing biopsy specimens, plasma, primary cell culture, 3-D tissue modeling, and mouse models of EoE. Additionally, Dr. Wechsler is involved in several clinical studies in collaboration with Barry Wershil, MD, and Amir Kagalwalla, MD. These studies are primarily focused on understanding the natural history of EoE and improving treatment options and outcomes.