The Eosinophilic Gastrointestinal Diseases (EGID) Program has several active studies at the present time including those listed below.
Potential Non-Invasive Biomarkers as a Surrogate to Repeated Histologic Evaluation to Assess Esophageal Inflammation
Currently, the only way doctors can diagnose the damage of eosinophilic esophagitis (EoE) is by performing an endoscopy with biopsy. We have special laboratory tests that may help us understand the causes of esophageal diseases. Tissues, blood and urine obtained during this study will be used to better understand why these diseases happen. We hope to find out how the esophagus changes and what is causing this to happen.
Evaluation of Esophageal Inflammation (The "String Test")
Doctors often recommend an endoscopy when they believe children may have a problem with the esophagus. We would like to find new ways in the future to study the esophagus without having to do an endoscopy. We have found that liquids released into the esophagus can stick to the string. By studying these liquids we hope to learn more about children’s diseases and find better ways to diagnose and/or treat them.
A Prospective Study of the Four Food Elimination Diet for Treatment of Eosinophilic Esophagitis
This prospective multi-center study eliminating the four most common (cow's milk, wheat, egg and soy) food triggers, will primarily assess the histologic response in a cohort of children and will attempt to validate the findings of the retrospective study already published. This study will also characterize patient demographics, symptoms and histologic changes associated with the four food elimination process.
Cow’s Milk Elimination for Treatment of Eosinophilic Esophagitis
This prospective study eliminating only cow’s milk proteins, which are a common cause of esophageal inflammation in patients with eosinophilic esophagitis, will assess the histologic response in a cohort of children and will attempt to validate the findings of a previously published retrospective study. This study will also characterize patient demographics, symptoms and histologic changes associated with the single food elimination of milk process.
Eosinophilic Esophagitis Database Project
This study aims to collect and analyze data from EoE patients seen at Lurie Children's to better understand the etiology, pathogenesis and clinical presentation of EoE. With this information, we hope to better define its association with other atopic conditions including reactive airway disease, seasonal allergies and atopic dermatitis. The database will allow clinicians to better evaluate the effectiveness of therapeutic strategies used to treat patients with EoE.
Development, Validation and Evaluation of an Adult and Pediatric Eosinophilic Esophagitis Activity Index: A Prospective Multicenter Study
This three-year project, carried out in cooperation with international EoE experts, aims at the development of an activity index for adult and pediatric EoE patients that will be used in future clinical trials as well as observational studies. Locations: 25 locations in the US, Canada, Switzerland, and the UK.