Chronic granulomatous disease is a disorder that causes the immune system to malfunction, resulting in a form of immunodeficiency. When the immune system is weak, recurrent bacterial and fungal infections can result.
Individuals with this condition can develop granulomas (inflamed areas) in various parts of the body, causing tissue damage. These symptoms of chronic granulomatous disease usually appear in childhood.
People with this condition may have serious infection every three to four years, most often in the lungs (called pneumonitis), but may also occur in the skin, liver, and lymph nodes. Less commonly, granulomas may appear in the gastrointestinal and genitourinary tracts.