What to Expect
Standard therapy for chronic GVHD is corticosteroids (prednisone) with a calcineurin inhibitor, such as cyclosporine. Every effort is made to lower prednisone to the lowest amount necessary, in order to minimize the side effects of the medication. If your child does not improve on this regimen, we can recommend a number of different therapies. We have significant expertise with extracorporeal photopheresis and pentostatin.
Both of these therapies appear to improve sclerotic manifestations of GVHD, which are often very difficult to treat. We also have experience with other medications that can be used to treat GVHD, such as infliximab, etanercept and sirolimus.