Our expert team in the Graft-Versus-Host Disease (GVHD) Program at Lurie Children’s is well-equipped to treat this serious condition. Chronic GVHD is a known complication of allogeneic stem cell transplant. With chronic GVHD, the new (donor's) immune system attacks the recipient's body. It is similar to an autoimmune process and creates fibrous tissue or scarring. The incidence varies depending upon the stem cell source used, the age of patient and donor, and other risk factors.
Chronic GVHD may develop following acute GVHD. It may appear after acute GVHD has resolved, or it may occur without any previous acute GVHD. There are many symptoms that need to be evaluated, as this chronic condition may affect one or more organs.