A lack of antibodies in the blood creates conditions where the body does not respond normally to foreign substances in the body. This can be caused by a deficiency in all immunoglobulin levels (called Common Variable Immune Deficiency, CVID) or in just one of two, such as those that protect the respiratory system. The latter is called Specific Antibody Deficiency, or SAD. CVID is thought to be a genetic defect. SAD, in most cases, improves as the child ages.
Both conditions may result in recurring infections, excessive inflammation, periodic fevers, and may result in long-term damage to specific organs.
Immunoglobulin replacement therapy and broad-spectrum antibiotics are usually effective in strengthening the body’s ability to fight these attacks on the body’s systems.