Cayuse: Research Suite

The Cayuse Research Suite provides Lurie Children's investigators and research staff with a fully electronic research management system. This integrated, web-based electronic system allows investigators and research staff to submit grant applications, proposal approvals, award documentation and subcontracts, and IRB protocols using one username and password.


  • Cayuse Access Form- to obtain login credentials please complete this form and provide it to the IRB or OSP
    • First time visitors, click here to set your password using the provided login credentials
  • For direct login to the Cayuse Research Suite, click here. Select the desired research administration suite to access the submission forms: Cayuse SP, Cayuse 424 or Cayuse IRB.
  • Cayuse password Reset

Cayuse 424 and SP

Cayuse 424 is the platform for completion and submission of federal grant proposals, delivered over a secure web connection. Cayuse SP is a sponsored project (SP) life cycle management solution that provides access to an investigator's entire research portfolio. For questions regarding Cayuse 424 or SP, please contact the Office of Sponsored Programs using the staff directory.

Cayuse 424 and SP Useful Links:

Cayuse IRB

Cayuse IRB is the web-based electronic submission system for all human subjects research protocols and projects. It uses smart-forms that are easy to navigate and require only the completion of relevant questions/sections. Cayuse IRB may be accessed from any device with internet access with the following browers: Mozilla Firefox, Chrome, Internet Explorer, or Safari. For questions regarding Cayuse IRB, please contact

ORIC staff is available to help train new users on Cayuse IRB at the downtown office room #19-376 by appointment during normal office hours (Mondays of IRB Meeting Days, Tuesdays and Thursdays, 9am-4pm)

Cayuse IRB Routing

  • All new IRB submissions require certification and sign-off by the assigned Division and Department Head(s). For more information regarding the certification and sign-off pathways, please click this link.
  • For more information about the IRB submission process, IRB Tracking, and Cayuse IRB Tasks, please click this link.

Cayuse IRB Useful Links

  • Cayuse IRB Overview
  • For access and questions related to Cayuse IRB, email or 312.503.7110.