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⚠ COVID-19 INFORMATION: Resources, Vaccine Information
We are particularly interested in establishing a pre-clinical rationale for clinical trials of various antitumor compounds. We have optimized systems of both in vitro and in vivo assays to evaluate the antitumor effects of novel compounds on cell proliferation, apoptosis, differentiation, cellular senescence, colony forming efficiency, and tumorigenicity. In addition to collaborating with various pharmaceutical companies for examination of therapeutic efficacies in our PDOX animal models, we also conduct high-througput drug screening by examining ~8,000 drugs at same time. Our laboratory works closely with clinical investigators to quickly translate our pre-clinical findings into clinical trials; 4 clinical trials for pediatric brain tumors patients have resulted directly from our laboratory research.
We are committed to share our established PDOX models and PDOX derived cell lines with other investigators through a fully executed material transfer agreement. For those interested in obtaining our PDOX models, please contact the PI, Dr. Xiao-Nan Li, at xli@luriechildrens.org or xiaonan.li@northwestern.edu.
NIH/NCI Patient-Derived Models of Cancer (UO1) (2020-2025)
NIH/NCI Pediatric Preclinical Testing Consortium (UO1)(2015-2020)
NIH/NCI RO1 (2014-2018)
Cancer Prevention & Research Institute of Texas (CPRIT) RP-1801312, 2018
The Cure Starts Now Foundation (2017-2019)
Cancer Prevention & Research Institute of Texas (CPRIT) RP-170169, 2016
Cancer Prevention & Research Institute of Texas (CPRIT) RP150032, 2014
Golfers Against Cancer (2016-2018)
The Cure Starts Now Foundation (2015-2017)
DIANA HELIS HENRY AND ADRIENNE HELIS MALVIN MEDICAL RESEARCH FOUNDATIONS (2015-2018)
Golfers Against Cancer (2015-2016)
The Cure Starts Now Foundation (2014)
Congressionally Directed Medical Research Programs (CDMRP) DOD (2011-2012)
Accelerate Brain Cancer Cure (2009-2010)
Cancer Fighters of Houston (2008)
National Brain Tumor Society (2004-2005)
Children's Brain Tumor Foundation (2003-2005)
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Hovestadt V, Smith KS, Bihannic L, Filbin MG, Shaw ML, Baumgartner A, DeWitt JC, Groves A, Mayr L, Weisman HR, Richman AR, Shore ME, Goumnerova L, Rosencrance C, Carter RA, Phoenix TN, Hadley JL, Tong Y, Houston J, Ashmun RA, DeCuypere M, Sharma T, Flasch D, Silkov A, Ligon KL, Pomeroy SL, Rivera MN, Rozenblatt-Rosen O, Rusert JM, Wechsler-Reya RJ, Li XN, Peyrl A, Gojo J, Kirchhofer D, Lötsch D, Czech T, Dorfer C, Haberler C, Geyeregger R, Halfmann A, Gawad C, Easton J, Pfister SM, Regev A, Gajjar A, Orr BA, Slavc I, Robinson GW, Bernstein BE, Suvà ML, Northcott PA. Resolving medulloblastoma cellular architecture by single-cell genomics. Nature. 2019 Aug;572(7767):74-79. doi: 10.1038/s41586-019-1434-6. Epub 2019 Jul 24. PMID: 31341285 Free PMC Article
Sin-Chan P, Mumal I, Suwal T, Ho B, Fan X, Singh I, Du Y, Lu M, Patel N, Torchia J, Popovski D, Fouladi M, Guilhamon P, Hansford JR, Leary S, Hoffman LM, Mulcahy Levy JM, Lassaletta A, Solano-Paez P, Rivas E, Reddy A, Gillespie GY, Gupta N, Van Meter TE, Nakamura H, Wong TT, Ra YS, Kim SK, Massimi L, Grundy RG, Fangusaro J, Johnston D, Chan J, Lafay-Cousin L, Hwang EI, Wang Y, Catchpoole D, Michaud J, Ellezam B, Ramanujachar R, Lindsay H, Taylor MD, Hawkins CE, Bouffet E, Jabado N, Singh SK, Kleinman CL, Barsyte-Lovejoy D, Li XN, Dirks PB, Lin CY, Mack SC, Rich JN, Huang A. A C19MC-LIN28A-MYCN Oncogenic Circuit Driven by Hijacked Super-enhancers Is a Distinct Therapeutic Vulnerability in ETMRs: A Lethal Brain Tumor. Cancer Cell. 2019 Jul 8;36(1):51-67.e7. doi: 10.1016/j.ccell.2019.06.002. PMID: 31287992 Free Article
Dobson THW, Tao RH, Swaminathan J, Maegawa S, Shaik S, Bravo-Alegria J, Sharma A, Kennis B, Yang Y, Callegari K, Haltom AR, Taylor P, Kogiso M, Qi L, Khatua S, Goldman S, Lulla RR, Fangusaro J, MacDonald TJ, Li XN, Hawkins C, Rajaram V, Gopalakrishnan V. Transcriptional repressor REST drives lineage stage-specific chromatin compaction at Ptch1 and increases AKT activation in a mouse model of medulloblastoma. Sci Signal. 2019 Jan 22;12(565). pii: eaan8680. doi: 10.1126/scisignal.aan8680. PMID: 30670636
Huang L, Garrett Injac S, Cui K, Braun F, Lin Q, Du Y, Zhang H, Kogiso M, Lindsay H, Zhao S, Baxter P, Adekunle A, Man TK, Zhao H, Li XN, Lau CC, Wong STC. Systems biology-based drug repositioning identifies digoxin as a potential therapy for groups 3 and 4 medulloblastoma. Sci Transl Med. 2018 Oct 24;10(464). pii: eaat0150. doi: 10.1126/scitranslmed.aat0150. PMID: 30355798 Free PMC Article
Purzner T, Purzner J, Buckstaff T, Cozza G, Gholamin S, Rusert JM, Hartl TA, Sanders J, Conley N, Ge X, Langan M, Ramaswamy V, Ellis L, Litzenburger U, Bolin S, Theruvath J, Nitta R, Qi L, Li XN, Li G, Taylor MD, Wechsler-Reya RJ, Pinna LA, Cho YJ, Fuller MT, Elias JE, Scott MP. Developmental phosphoproteomics identifies the kinase CK2 as a driver of Hedgehog signaling and a therapeutic target in medulloblastoma. Sci Signal. 2018 Sep 11;11(547). pii: eaau5147. doi: 10.1126/scisignal.aau5147. PMID: 30206138 Free PMC Article
Wu F, Cheng G, Yao Y, Kogiso M, Jiang H, Li XN, Song Y. Inhibition of Mutated Isocitrate Dehydrogenase 1 in Cancer. Med Chem. 2018;14(7):715-724. doi: 10.2174/1573406414666180524093659. PMID: 29792149 Free PMC Article
Berlow NE, Svalina MN, Quist MJ, Settelmeyer TP, Zherebitskiy V, Kogiso M, Qi L, Du Y, Hawkins CE, Hulleman E, Li XN, Gultekin SH, Keller C. IL-13 receptors as possible therapeutic targets in diffuse intrinsic pontine glioma. PLoS One. 2018 Apr 5;13(4):e0193565. doi: 10.1371/journal.pone.0193565. eCollection 2018. PMID: 29621254 Free PMC Article
Targeting a Weak Link in Pediatric Brain Cancer
Xiao-Nan Li, MD, PhD, Professor of Pediatrics - Hematology, Oncology and Stem Cell Transplantation