What is the evidence for using hydroxyurea for secondary stroke prevention?

Lebensburger, J. D.; DeBaun, M. R.; Thompson, A. A.

Hematology Am Soc Hematol Educ Program. 2011 Dec 14; 2011:440-2


A 10-year-old male patient with hemoglobin SS suffered a stroke at 7 years of age and was initially transfused at the time of presentation to lower the hemoglobin S concentration to < 30%. You are asked by the family if their child can be treated with oral hydroxyurea rather than monthly transfusions for the secondary prevention of strokes.

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