Testosterone Levels in Pre-Menopausal Women are Associated With Nonalcoholic Fatty Liver Disease in Midlife

Sarkar, M.; Wellons, M.; Cedars, M. I.; VanWagner, L.; Gunderson, E. P.; Ajmera, V.; Torchen, L.; Siscovick, D.; Carr, J. J.; Terry, J. G.; Rinella, M.; Lewis, C. E.; Terrault, N.

Am J Gastroenterol. 2017 Mar 16

Abstract

OBJECTIVES: Young women with hyperandrogenism have high risk of metabolic co-morbidities, including increased risk of nonalcoholic fatty liver disease (NAFLD). Whether testosterone (the predominant androgen) is associated with NAFLD independent of metabolic co-factors is unclear. Additionally, whether testosterone confers increased risk of NAFLD in women without hyperandrogenism is unknown. METHODS: Among women in the prospective population-based multicenter Coronary Artery Risk Development in Young Adults (CARDIA) study, we assessed whether free testosterone levels measured at Year 2 (1987-1988) were associated with prevalent NAFLD at Year 25 (2010-2011) (n=1052). NAFLD was defined using noncontrast abdominal CT scan with liver attenuation

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