Short term ibrutinib therapy suppresses skin test responses and eliminates IgE-mediated basophil activation in adults with peanut or tree nut allergy

Dispenza, M. C.; Pongracic, J. A.; Singh, A. M.; Bochner, B. S.

J Allergy Clin Immunol. 2018 Jan 24

Abstract

Two doses of ibrutinib significantly reduced skin prick test area and anti-IgE-induced basophil activation responses in peanut and tree nut allergic adults. Ibrutinib or other BTK inhibitors could potentially be used to prevent anaphylaxis.

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