Short sleep duration is associated with insulin resistance independent of adiposity in Chinese adult twins

Liu, R.; Zee, P. C.; Chervin, R. D.; Arguelles, L. M.; Birne, J.; Zhang, S.; Christoffel, K. K.; Brickman, W. J.; Zimmerman, D.; Wang, B.; Wang, G.; Xu, X.; Wang, X.

Sleep Med. 2011 Sep 24; 12(9):914-9

Abstract

OBJECTIVE: To investigate the association between sleep duration and insulin resistance in rural Chinese adults and examine whether any such associations are independent of adiposity. METHODS: This is a cross-sectional analysis of 854 men and 640 women aged 20 to 70 years from the Anqing Twin Cohort. The following measures were obtained for each subject: Body mass index (BMI) and percentage of trunk fat (%TF), fasting plasma glucose, homeostatic model assessment of insulin resistance index (HOMA-IR), self-reported sleep duration and measures of snoring and sleep disturbance from the Pittsburgh Sleep Quality Indices (PSQI) questionnaire were modified for a Chinese population. Multivariate linear regressions were applied to examine the association of sleep duration with HOMA-IR, with and without adjustment for adiposity variables, along with other relevant covariates. RESULTS: In this sample of relatively lean rural Chinese adults, short sleep duration was associated with HOMA-IR in women but not in men. In women, short (7 to 8 h/night) was not significantly associated with HOMA-IR. CONCLUSION: In this rural Chinese cohort, short sleep duration is independently associated with increased insulin resistance among women only, even after adjusting for adiposity and other potential confounders.

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