Salamanders and fish can regenerate lost structures - why can't we?

Simon, H. G.

BMC Biol. 2012 Mar 1; 10:15

Abstract

ABSTRACT: The recent introduction of in vivo lineage-tracing techniques using fluorescently labeled cells challenged the long-standing view that complete dedifferentiation is a major force driving vertebrate tissue regeneration. The report in BMC Developmental Biology by Juan Carlos Izpisua Belmonte and colleagues adds a new twist to a rapidly evolving view of the origin of blastemal cells. As classic and recent experimental findings are considered together, a new perspective on vertebrate muscle regeneration is emerging.See research article http://www.biomedcentral.com/1471-213X/12/9.

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