Reactive oxygen species in cancer: a dance with the devil

Schumacker, P. T.

Cancer Cell. 2015 Feb 12; 27(2):156-7


Reactive oxygen species (ROS) can initiate cancer, but oxidant generation in tumors leaves them vulnerable to further stresses. In this issue of Cancer Cell, Harris and colleagues show that augmenting oxidant stress in normal cells limits tumor initiation and progression. Hence, strategic targeting of antioxidant systems may undermine survival of new tumor cells.

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