Randomized Trial of Late Surfactant Treatment in Ventilated Preterm Infants Receiving Inhaled Nitric Oxide

Ballard, R. A.; Keller, R. L.; Black, D. M.; Ballard, P. L.; Merrill, J. D.; Eichenwald, E. C.; Truog, W. E.; Mammel, M. C.; Steinhorn, R. H.; Rogers, E. E.; Ryan, R. M.; Durand, D. J.; Asselin, J. M.; Bendel, C. M.; Bendel-Stenzel, E. M.; Courtney, S. E.; Dhanireddy, R.; Hudak, M. L.; Koch, F. R.; Mayock, D. E.; McKay, V. J.; O'Shea, T. M.; Porta, N. F.; Wadhawan, R.; Palermo, L.

J Pediatr. 2015 Oct 27; 168:23-29.e4

Abstract

OBJECTIVE: To assess whether late surfactant treatment in extremely low gestational age (GA) newborn infants requiring ventilation at 7-14 days, who often have surfactant deficiency and dysfunction, safely improves survival without bronchopulmonary dysplasia (BPD). STUDY DESIGN: Extremely low GA newborn infants (GA

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