Putative multifunctional signature of lung metastases in dedifferentiated chondrosarcoma

Malchenko, S.; Seftor, E. A.; Nikolsky, Y.; Hasegawa, S. L.; Kuo, S.; Stevens, J. W.; Poyarkov, S.; Nikolskaya, T.; Kucaba, T.; Wang, M.; Abdulkawy, H.; Casavant, T.; Morcuende, J.; Buckwalter, J.; Hohl, R.; Deyoung, B.; Kernstine, K.; Bonaldo Mde, F.; Hendrix, M. J.; Soares, M. B.; Soares, V. M.

Sarcoma. 2012 Mar 27; 2012:820254

Abstract

Chondrosarcomas are among the most malignant skeletal tumors. Dedifferentiated chondrosarcoma is a highly aggressive subtype of chondrosarcoma, with lung metastases developing within a few months of diagnosis in 90% of patients. In this paper we performed comparative analyses of the transcriptomes of five individual metastatic lung lesions that were surgically resected from a patient with dedifferentiated chondrosarcoma. We document for the first time a high heterogeneity of gene expression profiles among the individual lung metastases. Moreover, we reveal a signature of "multifunctional" genes that are expressed in all metastatic lung lesions. Also, for the first time, we document the occurrence of massive macrophage infiltration in dedifferentiated chondrosarcoma lung metastases.

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