Placental pathologic changes of maternal vascular underperfusion in bronchopulmonary dysplasia and pulmonary hypertension

Mestan, K. K.; Check, J.; Minturn, L.; Yallapragada, S.; Farrow, K. N.; Liu, X.; Su, E.; Porta, N.; Gotteiner, N.; Ernst, L. M.

Placenta. 2014 Jun 8; 35(8):570-4

Abstract

INTRODUCTION: Bronchopulmonary dysplasia (BPD) is the most common chronic lung disease of infancy, and BPD-associated pulmonary hypertension (PH) is a serious complication that can negatively impact later childhood health. There is growing evidence that lung injury leading to BPD and PH is due to chronic fetal hypoxia-ischemia. The purpose of this study was to investigate whether placental pathologic changes of maternal vascular underperfusion (MVU) are associated with BPD, and further increased with PH. METHODS: We conducted a 5-year retrospective cohort study of premature infants born

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