Pilot Study of the Association of the DDAH2 -449G Polymorphism with Asymmetric Dimethylarginine and Hemodynamic Shock in Pediatric Sepsis

Weiss, S. L.; Yu, M.; Jennings, L.; Haymond, S.; Zhang, G.; Wainwright, M. S.

PLoS One. 2012 Mar 20; 7(3):e33355

Abstract

BACKGROUND: Genetic variability in the regulation of the nitric oxide (NO) pathway may influence hemodynamic changes in pediatric sepsis. We sought to determine whether functional polymorphisms in DDAH2, which metabolizes the NO synthase inhibitor asymmetric dimethylarginine (ADMA), are associated with susceptibility to sepsis, plasma ADMA, distinct hemodynamic states, and vasopressor requirements in pediatric septic shock. METHODOLOGY/PRINCIPAL FINDINGS: In a prospective study, blood and buccal swabs were obtained from 82 patients

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