OBJECTIVES: Erythema annulare centrifugum (EAC) is an uncommon eruption that may be a hypersensitivity reaction. Treatment of EAC is best accomplished by eliminating the underlying cause. Although many triggers have been reported, the inciting factor is unknown in most patients. We hypothesized that occult yeast overgrowth may trigger EAC in patients with EAC of unknown etiology. METHODS: Five children with EAC were treated empirically with oral fluconazole. These cases were retrospectively reviewed. RESULTS: Improvement was noted in all patients; three cleared entirely. Two patients experienced recurrences after successful treatment, which were treated with a second course of fluconazole. The treatment was well tolerated, without adverse effects. CONCLUSION: Oral fluconazole was an effective treatment in five children with EAC.