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Noninvasive Diagnosis of Infection Using Plasma Next-Generation Sequencing: A Single-Center Experience

Rossoff, J.; Chaudhury, S.; Soneji, M.; Patel, S. J.; Kwon, S.; Armstrong, A.; Muller, W. J.

Open Forum Infect Dis. 2019 Aug 4; 6(8)

Abstract

Pediatric patients frequently present with illnesses strongly suggesting infection, but without a clearly identified etiology. Our center has recently added a commercially available plasma metagenomic sequencing assay to its available diagnostic testing. Our experience with the first 100 tests suggests that this technology has good clinical performance with >90% sensitivity.

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