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Late administration of surfactant replacement therapy increases surfactant protein-B content: a randomized pilot study

Keller, R. L.; Merrill, J. D.; Black, D. M.; Steinhorn, R. H.; Eichenwald, E. C.; Durand, D. J.; Ryan, R. M.; Truog, W. E.; Courtney, S. E.; Ballard, P. L.; Ballard, R. A.

Pediatr Res. 2012 Oct 6; 72(6):613-9


BACKGROUND: Surfactant dysfunction may contribute to the development of bronchopulmonary dysplasia (BPD) in persistently ventilated preterm infants. We conducted a multicenter randomized, blinded, pilot study to assess the safety and efficacy of late administration of doses of a surfactant protein-B (SP-B)-containing surfactant (calfactant) in combination with prolonged inhaled nitric oxide (iNO) in infants

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