iPSCs Offer a New Look at GATA1-Trisomy 21 Cooperation

McNulty, M.; Crispino, J. D.

Cell Stem Cell. 2016 May 8; 18(5):563-4


GATA1 mutations and trisomy 21 are inextricably linked in the neonatal leukemia of children with Down syndrome (DS). A recent report by Banno et al. (2016) sheds new light on the mechanism of the synergy between these genetic alterations by modeling hematopoietic abnormalities with patient-derived induced pluripotent stem cells.

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