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Infectious Diseases Society of America Guidelines on the Treatment and Management of Patients with COVID-19

Bhimraj, A.; Morgan, R. L.; Shumaker, A. H.; Lavergne, V.; Baden, L.; Cheng, V. C.; Edwards, K. M.; Gandhi, R.; Muller, W. J.; O'Horo, J. C.; Shoham, S.; Murad, M. H.; Mustafa, R. A.; Sultan, S.; Falck-Ytter, Y.

Clin Infect Dis. 2020 Apr 28

Abstract

BACKGROUND: There are many pharmacologic therapies that are being used or considered for treatment of COVID-19. There is a need for frequently updated practice guidelines on their use, based on critical evaluation of rapidly emerging literature. OBJECTIVE: Develop evidence-based rapid guidelines intended to support patients, clinicians and other health-care professionals in their decisions about treatment and management of patients with COVID-19. METHODS: IDSA formed a multidisciplinary guideline panel of infectious disease clinicians, pharmacists, and methodologists with varied areas of expertise. Process followed a rapid recommendation checklist. The panel prioritized questions and outcomes. Then a systematic review of the peer-reviewed and grey literature was conducted. The Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach was used to assess the certainty of evidence and make recommendations. RESULTS: The IDSA guideline panel agreed on 7 treatment recommendations and provided narrative summaries of other treatments undergoing evaluations. CONCLUSIONS: The panel expressed the overarching goal that patients be recruited into ongoing trials, which would provide much needed evidence on the efficacy and safety of various therapies for COVID-19, given that we could not make a determination whether the benefits outweigh harms for most treatments.

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