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Genome-wide association study of inhaled corticosteroid response in admixed children with asthma

Hernandez-Pacheco, N.; Farzan, N.; Francis, B.; Karimi, L.; Repnik, K.; Vijverberg, S. J.; Soares, P.; Schieck, M.; Gorenjak, M.; Forno, E.; Eng, C.; Oh, S. S.; Perez-Mendez, L.; Berce, V.; Tavendale, R.; Samedy, L. A.; Hunstman, S.; Hu, D.; Meade, K.; Farber, H. J.; Avila, P. C.; Serebrisky, D.; Thyne, S. M.; Brigino-Buenaventura, E.; Rodriguez-Cintron, W.; Sen, S.; Kumar, R.; Lenoir, M.; Rodriguez-Santana, J. R.; Celedon, J. C.; Mukhopadhyay, S.; Potocnik, U.; Pirmohamed, M.; Verhamme, K. M.; Kabesch, M.; Palmer, C. N. A.; Hawcutt, D. B.; Flores, C.; Maitland-van der Zee, A. H.; Burchard, E. G.; Pino-Yanes, M.

Clin Exp Allergy. 2019 Jan 31; 49(6):789-798

Abstract

BACKGROUND: Inhaled corticosteroids (ICS) are the most widely prescribed and effective medication to control asthma symptoms and exacerbations. However, many children still have asthma exacerbations despite treatment, particularly in admixed populations, such as Puerto Ricans and African Americans. A few genome-wide association studies (GWAS) have been performed in European and Asian populations, and they have demonstrated the importance of the genetic component in ICS response. OBJECTIVE: We aimed to identify genetic variants associated with asthma exacerbations in admixed children treated with ICS and to validate previous GWAS findings. METHODS: A meta-analysis of two GWAS of asthma exacerbations was performed in 1347 admixed children treated with ICS (Hispanics/Latinos and African Americans), analysing 8.7 million genetic variants. Those with P

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