Evaluation of asymmetric dimethylarginine, arginine, and carnitine metabolism in pediatric sepsis

Weiss, S. L.; Haymond, S.; Ranaivo, H. R.; Wang, D.; De Jesus, V. R.; Chace, D. H.; Wainwright, M. S.

Pediatr Crit Care Med. 2012 Mar 31; 13(4):e210-e218

Abstract

OBJECTIVE:: Increased plasma concentrations of the endogenous nitric oxide synthase inhibitor, asymmetric dimethylarginine, decreased arginine bioavailability, and mitochondrial dysfunction have been reported in adult sepsis. We studied whether asymmetric dimethylarginine, arginine, and carnitine metabolism (a measure of mitochondrial dysfunction) are altered in pediatric sepsis and whether these are clinically useful biomarkers. DESIGN:: Prospective, observational study. SETTING:: Pediatric intensive care unit at an academic medical center. PATIENTS:: Ninety patients

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