Enteral Feeding during Indomethacin and Ibuprofen Treatment of a Patent Ductus Arteriosus

Clyman, R.; Wickremasinghe, A.; Jhaveri, N.; Hassinger, D. C.; Attridge, J. T.; Sanocka, U.; Polin, R.; Gillam-Krakauer, M.; Reese, J.; Mammel, M.; Couser, R.; Mulrooney, N.; Yanowitz, T. D.; Derrick, M.; Jegatheesan, P.; Walsh, M.; Fujii, A.; Porta, N.; Carey, W. A.; Swanson, J. R.

J Pediatr. 2013 Mar 12; 163(2):406-411 e4


OBJECTIVE: To test the hypothesis that infants who are just being introduced to enteral feedings will advance to full enteral nutrition at a faster rate if they receive "trophic" (15 mL/kg/d) enteral feedings while receiving indomethacin or ibuprofen treatment for patent ductus arteriosus. STUDY DESIGN: Infants were eligible for the study if they were 23(1/7)-30(6/7) weeks' gestation, weighed 401-1250 g at birth, received maximum enteral volumes

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