Does genetic regulation of IgE begin in utero? Evidence from T(H)1/T(H)2 gene polymorphisms and cord blood total IgE

Hong, X.; Tsai, H. J.; Liu, X.; Arguelles, L.; Kumar, R.; Wang, G.; Kuptsova-Clarkson, N.; Pearson, C.; Ortiz, K.; Bonzagni, A.; Apollon, S.; Fu, L.; Pongracic, J. A.; Schleimer, R.; Holt, P. G.; Bauchner, H.; Wang, X.

J Allergy Clin Immunol. 2010 Nov 6; 126(5):1059-67, 1067 e1

Abstract

BACKGROUND: Elucidation of early life factors is critical to understand the development of allergic diseases, especially those manifesting in early life such as food allergies and atopic dermatitis. Cord blood IgE (CBIgE) is a recognized risk factor for the subsequent development of allergic diseases. In contrast with numerous genetic studies of total serum IgE in children and adults, limited genetic studies on CBIgE have been conducted. OBJECTIVE: To test the associations between functional or tagging single nucleotide polymorphisms (SNPs) in genes involved in the T(H)1/T(H)2 pathway and CBIgE in a large US inner-city birth cohort. METHODS: CBIgE, measured by Phadia ImmnunoCAP, was analyzed as a continuous and a binary variable. The association of each SNP with the 2 outcomes was tested using tobit and logistic regression models, respectively, with adjustment for pertinent covariates, ancestral proportion, and multiple testing. Ethnic heterogeneity and gene-gene interactions were also explored. RESULTS: Three SNPs (rs1800925, rs2069743, and rs1295686) in the IL13 gene were significantly associated with CBIgE concentration (P

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