CD4-T cell-restricted IL-2 signaling defect in a patient with a novel IFNGR1-deficiency

Khanolkar, A.; Kirschmann, D. A.; Caparelli, E. A.; Wilks, J. D.; Cerullo, J. M.; Bergerson, J. R. E.; Jennings, L. J.; Fuleihan, R. L.

J Allergy Clin Immunol. 2017 Sep 21

Abstract

In depth analysis of immune function in a patient with a defined defect in IFNgammaR1 expression additionally identified an IL-2 associated signaling deficiency that was restricted primarily to the circulating CD4 T cell subset.

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