BMP meets AML: induction of BMP signaling by a novel fusion gene promotes pediatric acute leukemia

Crispino, J. D.; Le Beau, M. M.

Cancer Cell. 2012 Nov 17; 22(5):567-8


In this issue of Cancer Cell, Gruber et al. report that a significant proportion of children with acute megakaryoblastic leukemia acquire a translocation that confers enhanced BMP signaling and promotes self-renewal of hematopoietic progenitors. This study presents novel therapeutic targets that may lead to improved therapies for this aggressive leukemia.

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