Anesthetic neurotoxicity--clinical implications of animal models

Rappaport, B. A.; Suresh, S.; Hertz, S.; Evers, A. S.; Orser, B. A.

N Engl J Med. 2015 Feb 26; 372(9):796-7


Some anesthetics and sedatives have been shown to cause neurotoxic effects in laboratory animals. The FDA collaboration SmartTots recommends undertaking large-scale clinical studies and avoiding nonurgent surgical procedures requiring anesthesia in children younger than 3 years of age.

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