Air Pollution and Lung Function in Minority Youth with Asthma in the GALA II (Genes-Environments and Admixture in Latino Americans) and SAGE II (Study of African Americans, Asthma, Genes, and Environments) Studies

Neophytou, A. M.; White, M. J.; Oh, S. S.; Thakur, N.; Galanter, J. M.; Nishimura, K. K.; Pino-Yanes, M.; Torgerson, D. G.; Gignoux, C. R.; Eng, C.; Nguyen, E. A.; Hu, D.; Mak, A. C.; Kumar, R.; Seibold, M. A.; Davis, A.; Farber, H. J.; Meade, K.; Avila, P. C.; Serebrisky, D.; Lenoir, M. A.; Brigino-Buenaventura, E.; Rodriguez-Cintron, W.; Bibbins-Domingo, K.; Thyne, S. M.; Williams, L. K.; Sen, S.; Gilliland, F. D.; Gauderman, W. J.; Rodriguez-Santana, J. R.; Lurmann, F.; Balmes, J. R.; Eisen, E. A.; Burchard, E. G.

Am J Respir Crit Care Med. 2016 Jan 7; 193(11):1271-80

Abstract

RATIONALE: Adverse effects of exposures to ambient air pollution on lung function are well documented, but evidence in racial/ethnic minority children is lacking. OBJECTIVES: To assess the relationship between air pollution and lung function in minority children with asthma and possible modification by global genetic ancestry. METHODS: The study population consisted of 1,449 Latino and 519 African American children with asthma from five different geographical regions in the mainland United States and Puerto Rico. We examined five pollutants (particulate matter

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