A Prospective Birth Cohort Study on Maternal Cholesterol Levels and Offspring Attention Deficit Hyperactivity Disorder: New Insight on Sex Differences

Ji, Y.; Riley, A. W.; Lee, L. C.; Volk, H.; Hong, X.; Wang, G.; Angomas, R.; Stivers, T.; Wahl, A.; Ji, H.; Bartell, T. R.; Burd, I.; Paige, D.; Fallin, M. D.; Zuckerman, B.; Wang, X.

Brain Sci. 2018 Jan 4; 8(1)


Growing evidence suggests that maternal cholesterol levels are important in the offspring's brain growth and development. Previous studies on cholesterols and brain functions were mostly in adults. We sought to examine the prospective association between maternal cholesterol levels and the risk of attention deficit hyperactivity disorder (ADHD) in the offspring. We analyzed data from the Boston Birth Cohort, enrolled at birth and followed from birth up to age 15 years. The final analyses included 1479 mother-infant pairs: 303 children with ADHD, and 1176 neurotypical children without clinician-diagnosed neurodevelopmental disorders. The median age of the first diagnosis of ADHD was seven years. The multiple logistic regression results showed that a low maternal high-density lipoprotein level (

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