Randomized Control Trial of Fluid Therapy for Pediatric Diabetic Ketoacidosis

Official Title: Fluid Therapy and Cerebral Injury in Pediatric Diabetic Ketoacidosis

The investigators will conduct a randomized controlled trial comparing four different intravenous (IV) fluid treatment protocols for pediatric diabetic ketoacidosis (DKA). Two rates of rehydration will be compared; a more rapid rate and a slower rate. Within each of these two basic rehydration protocols, the investigators will vary the type of rehydration fluid used (0.9% saline or 0.45% saline). The investigators will compare the different treatments by conducting assessments of neurological injury, by measuring the frequency of significant cerebral edema, and by measuring long-term neurocognitive function.

Trainor, Jennifer L., MD

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Jennifer Trainor, MD