Heart And Lung Failure - Pediatric Insulin Titration Trial (HALF-PINT)

Official Title: Heart And Lung Failure - Pediatric Insulin Titration Trial (HALF-PINT)

Stress hyperglycemia, a state of abnormal metabolism with supra-normal blood glucose levels, is often seen in critically ill patients. Studies have shown mixed results regarding the benefit of tight glycemic control (TGC) in both children and adults. The Heart And Lung Failure - Pediatric Insulin Titration (HALF-PINT) trial is a multi-center, randomized clinical treatment trial comparing two ranges of glucose control in 1880 hyperglycemic critically ill children with heart and/or lung failure. Both target ranges of glucose control fall within the range of "usual care" for critically ill children managed in pediatric intensive care units. The purpose of the study is to determine the comparative effectiveness of tight glycemic control to a target range of 80-110 mg/dL (TGC-1, 4.4-6.1 mmol/L) vs. a target range of 150-180 mg/dL (TGC-2, 8.3-10.0 mmol/L) on hospital mortality and intensive care unit (ICU) length of stay (LOS) in hyperglycemic critically ill children with cardiovascular and/or respiratory failure. This will be accomplished using an explicit insulin titration algorithm and continuous glucose monitoring to safely achieve these glucose targets.
NCT01565941
Marsillio, Lauren E., MD
Interventional
No

Contact Information:

Avani Shukla

Clinical Research Associate

312-227-4000