In this project, we will maintain a library of intestine resected from children with bowel disease. We will use these tissue samples for the histological characterization for comparison with other diseased intestine. The size of the tissue sample resected will vary according to what is clinically determined by the surgeon. Only intestine that would otherwise be discarded will be collected for the tissue library. We will collect age, gender and diagnosis of the patient when obtaining the discarded tissue in the OR.
Although there is no direct benefit to the child, by characterizing and maintaining a library of tissue samples from children and neonates we may be better able to understand the pathogenesis of necrotizing enterocolitis. It will provide a source of reference to formulate better treatment for each disease.