Clinical Studies

Clinical research is very important because it is one of the best ways to improve patient care. Currently, hundreds of studies are taking place throughout Lurie Children's, including at the research institute, that involve many of our doctors, nurses, clinical research professionals, scientists and technicians.

Search below for a clinical study, or read more on our guide to clinical research for parents and children.

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Examining Benefits of HAART Continuation in Postpartum Mothers ID: NCT00955968

The purpose of this study is to see if pregnant women receiving highly active antiretroviral treatment (HAART) to prevent mother-to-child transmission of HIV will be healthier if, after delivery, they continue or stop HAART.00955968

Prediction of Delayed Excretion and Toxicity of High Dose Methotrexate in Children and Adolescents With ALL ID: NCT02133599

Each year approximately 2,900 children and adolescents less than 20 years old are diagnosed with acute lymphoblastic leukemia (ALL) in the United States. High-dose methotrexate (HDMTX; 5 g/m2) remains an important component of standard treatment for most ALL patients. However, high plasma and intracellular MTX concentrations (defined as a MTX...

Response and Biology-Based Risk Factor-Guided Therapy in Treating Younger Patients With Non-high Risk Neuroblastoma ID: NCT02176967

This phase III trial studies how well response and biology-based risk factor-guided therapy works in treating younger patients with non-high risk neuroblastoma. Sometimes a tumor may not need treatment until it progresses. In this case, observation may be sufficient. Measuring biomarkers in tumor cells may help plan when effective treatment is...

Longitudinal Observation of Pectus Carinatum Patients

We propose a prospective longitudinal observation study at Ann and Robert H. Lurie Children’s Hospital of pediatric patients with a chest wall deformity diagnosis of either congenital or acquired pectus carinatum. Our aim is to assess the precision and accuracy of the Rodin M4D White Light Scanner in preoperative evaluation of pectus carinatum...

Defining the pathophysiology of inflammatory bowel disease in human subjects

In this project, we will maintain a library of intestine resected from children with bowel disease. We will use these tissue samples for the histological characterization for comparison with other diseased intestine. The size of the tissue sample resected will vary according to what is clinically determined by the surgeon. Only intestine that...