Clinical Studies

Clinical research is very important because it is one of the best ways to improve patient care. Currently, hundreds of studies are taking place throughout Lurie Children's, including at the research institute, that involve many of our doctors, nurses, clinical research professionals, scientists and technicians.

Search below for a clinical study, or to see a more comprehensive listing of the clinical studies taking place at Lurie Children's, please use our link to the website.

You can learn more about the clinical research process on our guide to clinical research for parents and children.

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Antiviral Activity of Doses of JNJ 53718678 in Children With Respiratory Syncytial Virus Infection ID: NCT03656510

JNJ-53718678 is an investigational respiratory syncytial virus (RSV) specific fusion inhibitor and is under development for the treatment of RSV infection, which results in an upper and/or lower respiratory tract illness. The primary hypothesis of this study is that JNJ-53718678 has antiviral activity against RSV (that is, results in a decrease in...

A Study of Safety and Efficacy of MK-1986 Tedizolid Phosphate and Comparator in Subjects With Acute Bacterial Skin and Skin Structure Infections ID: NCT03176134

Participants will be randomized (3:1) to receive MK-1986 at a weight-based dose ≤200 mg/day, intravenous (IV) and/or oral suspension for 6 or 10 days, or comparator IV and/or oral per local standard of care for 10 or 14 days. The switch from IV to oral administration can be made at any time based on 1) no worsening of the primary skin lesion,...

Baloxavir Marboxil in Healthy Pediatric Participants From Birth to less than 1 Year With Influenza Like Symptoms ID: NCT03653364

This is a multicenter, single-arm, open-label study to assess the safety, pharmacokinetics, and efficacy of baloxavir marboxil in otherwise healthy pediatric patients from birth to <1 year with influenza-like symptoms. Patients will be screened on Day 1 and assigned to one of three cohorts, based upon their age, to receive a single oral dose of...

Pharmacokinetics and Safety of Commonly Used Drugs in Lactating Women and Breastfed Infants ID: NCT03511118

Over half of women in the US who are breastfeeding their infants take prescription drugs. You are being asked to participate in this study because you are breastfeeding your infant and are currently taking, as part of your medical care, at least one of the drugs we are studying. We are interested in studying drugs commonly prescribed to women who...

A Safety and PK Study of IV Eravacycline ID: NCT03696550

This is a Phase 1, open-label, multi-center study to determine the pharmacokinetics and safety of intravenous Eravacycline in Children with Suspected or Confirmed Bacterial Infection. Male and Female subjects from 8 to less than 18 years of age who fulfill the inclusion/exclusion criteria will be enrolled in this study.