Clinical Studies

Clinical research is very important because it is one of the best ways to improve patient care. Currently, hundreds of studies are taking place throughout Lurie Children's, including at the research institute, that involve many of our doctors, nurses, clinical research professionals, scientists and technicians.

Search below for a clinical study, or to see a more comprehensive listing of the clinical studies taking place at Lurie Children's, please use our link to the ClinicalTrials.gov website.

You can learn more about the clinical research process on our guide to clinical research for parents and children.

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Studies

Evaluating the Genetic Causes and Progression of Cholestatic Liver Diseases (LOGIC)

ClinicalTrials.gov ID: NCT00571272

Cholestasis is a condition in which bile is not properly transported from the liver to the small intestine. Cholestasis can be caused by an array of childhood diseases, including the genetic diseases Alagille syndrome (ALGS), alpha-1 antitrypsin (a-1AT) deficiency, bile acid synthesis and metabolism defects, and progressive familial intrahepatic...

Biliary Atresia Study in Infants and Children (BASIC)

ClinicalTrials.gov ID: NCT00345553

Little is known about the factors that cause biliary atresia nor the factors that influence disease progression. The purpose of this study is to collect the pertinent clinical information, genetic material and body fluid samples to enable investigators to address the following aims: To identify the gene or genes implicated in the etiology of BA;...

Biliary Atresia Research Consortium (PROBE)

ClinicalTrials.gov ID: NCT00061828

Biliary atresia and idiopathic neonatal hepatitis are the most common causes of jaundice and hyperbilirubinemia that continue beyond the newborn period. The long term goal of the Biliary Atresia Research Consortium (BARC) is to establish a database of clinical information and serum and tissue samples from children with biliary atresia (BA) and...

Cabozantinib in Treating Younger Patients With Recurrent or Refractory Solid Tumors

ClinicalTrials.gov ID: NCT01709435

This phase I trial studies the side effects and best dose of cabozantinib in treating younger patients with solid tumors that have come back or no longer respond to treatment. Cabozantinib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth.

Study of the Incidence of and Risk Factors for Fibrosing Colonopathy in US Patients with Cystic Fibrosis Treated with Pancreatic Enzyme Replacement Therapy

ClinicalTrials.gov ID: NCT01652157

This is a long-term study in cystic fibrosis patients who are participating in the Cystic Fibrosis Patient Registry to assess the occurrence and risk factors for a rare bowel disorder called fibrosing colonopathy (narrowing of the large intestine). Patients will be followed at their regular clinical care visits over a 10-year period and approached...