Clinical Studies

Clinical research is very important because it is one of the best ways to improve patient care. Currently, hundreds of studies are taking place throughout Lurie Children's, including at the research institute, that involve many of our doctors, nurses, clinical research professionals, scientists and technicians.

Search below for a clinical study, or read more on our guide to clinical research for parents and children.

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Clinical Decision Rules to Discriminate Bruising Caused by Physical Child Abuse from Bruising Caused by Accidental Trauma

Our objective is to conduct a definitive study to investigate the bruising characteristics in children less than 4 years of age due to abusive and accidental trauma and model the results into a highly sensitive and clinically sensible tool for identifying bruising caused by child abuse. This study is a multi-center NIH (NICHD) sponsored study. Our...

Safety and Pharmacokinetics of Raltegravir in HIV-1-Exposed Newborn Infants at High Risk of Acquiring HIV-1 Infection ID: NCT01780831

This study will evaluate the safety and pharmacokinetics (PKs) of raltegravir (RAL) given to HIV-1-exposed newborns at high risk of acquiring HIV-1 infection. (Pharmacokinetics are the various interactions between a drug and the body.) This study will also evaluate the appropriate dose of RAL to give to an infant to prevent the infant from getting...

Evaluating the Safety and Tolerability of Etravirine in HIV-1 Infected Infants and Children ID: NCT01504841

Non-nucleoside reverse transcriptase inhibitors (NNRTIs) are widely used as part of combination antiretroviral therapy (ART) for infants and children, but NNRTI resistance is increasing, leading to treatment failure. This study will test the safety, tolerability, and dosing levels of etravirine (ETR), a new NNRTI.

Evaluating the Safety and Immune Response to a Single Dose of a Respiratory Syncytial Virus (RSV) Vaccine in RSV-Seronegative Infants and Children ID: NCT01968083

Human respiratory syncytial virus (RSV) is a common cause of respiratory illness in infants and children. This study will evaluate the safety and immune response to an RSV vaccine in healthy RSV-naïve children.

Surveillance Monitoring for ART Toxicities Study in HIV Uninfected Children Born to HIV Infected Women ID: NCT01310023

SMARTT will estimate the incidence of conditions and diagnoses potentially related to in utero exposure to antiretroviral therapy and/or exposure in the first two months of life among children born of HIV-infected mothers