Clinical Studies

Clinical research is very important because it is one of the best ways to improve patient care. Currently, hundreds of studies are taking place throughout Lurie Children's, including at the research institute, that involve many of our doctors, nurses, clinical research professionals, scientists and technicians.

Search below for a clinical study, or to see a more comprehensive listing of the clinical studies taking place at Lurie Children's, please use our link to the ClinicalTrials.gov website.

You can learn more about the clinical research process on our guide to clinical research for parents and children.

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Studies

Prediction by Ultrasound of the Risk of Hepatic Cirrhosis in Cystic Fibrosis (PUSH)

ClinicalTrials.gov ID: NCT01144507

Advanced liver disease is a condition estimated to affect about seven percent of patients with CF, and is considered the third leasing cause of death among CF patients. There currently is no test or tool to identify CF children who are at risk of developing advanced liver disease. The aim of this study is to determine if sonographic findings...

STOP PIV - Phase 3 DAS181 Lower Tract PIV Infection in Immunocompromised Subjects

ClinicalTrials.gov ID: NCT03808922

This study will seek to enroll immunocompromised patients with Lower Tract parainfluenza infection

Evaluating the Safety and Pharmacokinetics of VRC01, A Potent Anti-HIV Neutralizing Monoclonal Antibody, in HIV-1 Exposed Infants

ClinicalTrials.gov ID: NCT02256631

VRC01 and VRC01LS are anti-HIV neutralizing monoclonal antibodies that may help prevent mother-to-child transmission of HIV. This study will enroll HIV-infected mothers who are at increased risk of passing HIV on to their children. The purpose of this study is to assess the safety and PK of VRC01 and VRC01LS in HIV-exposed infants. This study...

Evaluating the Infectivity, Safety, and Immunogenicity of the Recombinant Live-Attenuated Respiratory Syncytial Virus Vaccines RSV ΔNS2/Δ1313/I1314L or RSV 276 in RSV-Seronegative Infants 6 to 24 Months of Age

ClinicalTrials.gov ID: NCT03227029

The purpose of this study is to evaluate the infectivity, safety, and immunogenicity of the recombinant live-attenuated respiratory syncytial virus (RSV) vaccines RSV ΔNS2/Δ1313/I1314L or RSV 276 or placebo when delivered as nose drops to RSV-seronegative infants 6 to 24 months of age. This study is a companion study to CIR 321.

Pharmacokinetics, Pharmacodynamics, and Safety Profile of Understudied Drugs Administered to Children Per Standard of Care (POPS) (POPS or POP02)

ClinicalTrials.gov ID: NCT04278404

The study investigators are interested in learning more about how drugs, that are given to children by their health care provider, act in the bodies of children and young adults in hopes to find the most safe and effective dose for children. The primary objective of this study is to evaluate the PK of understudied drugs currently being...