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Clinical Studies

Clinical research is very important because it is one of the best ways to improve patient care. Currently, hundreds of studies are taking place throughout Lurie Children's, including at the research institute, that involve many of our doctors, nurses, clinical research professionals, scientists and technicians.

Search below for a clinical study, or to see a more comprehensive listing of the clinical studies taking place at Lurie Children's, please use our link to the ClinicalTrials.gov website.

You can learn more about the clinical research process on our guide to clinical research for parents and children.

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Studies

Bracing vs Casting in the Treatment of Idiopathic Early-Onset Scoliosis

ClinicalTrials.gov ID: NCT04500041

Idiopathic early onset scoliosis (IEOS) is a rare spinal deformity affecting approximately 40 of 100,000 children. Serial casting has been the most favored treatment, but casts are usually applied with the child under general anesthesia or sedation in the operating room. Although casting is effective at resolving curvature or delaying surgical...

Elucidating the Discoid Meniscus with Proposed New Classification System

Discoid meniscus is an abnormal meniscal variant where the meniscus is thickened and abnormally shaped. Historically, discoid meniscus has been categorized using several proposed classification systems, but that described by Watanabe et al. remains most widely accepted. There are cases however, in which type I, type II, and type III (Wrisberg...

Improving Medication Adherence in Adolescents Who Had a Liver Transplant (iMALT)

ClinicalTrials.gov ID: NCT03691220

Pediatric adolescent and young adult (age at enrollment ≥12 and < 18) transplant recipients will be eligible for participation in the study. Learn more.

The Pediatric ALL Evaluation and Trial (PALLET): A Randomized, Controlled Trial

Studies have shown the rising incidence of anterior cruciate ligament (ACL) injuries in children and adolescents. Pediatric patients are at a higher risk of graft failure than adults (3-4% compared to 12-19%) after ACL reconstruction. In the adult population, a growing number of studies have suggested that concomitant reconstruction of the...

A Study of Lirentelimab (AK002) in Patients With Active Eosinophilic Esophagitis

ClinicalTrials.gov ID: NCT04322708

This is a Phase 2/3, multi-center, randomized, double-blind, placebo-controlled study to assess the efficacy and safety of lirentelimab (AK002) given monthly for 6 doses in adult and adolescent patients with active eosinophilic esophagitis. Subjects who complete the randomized, double-blind, placebo-controlled treatment may have the option to...